Antiproteinuric Effect of Sparsentan in Patients with Genetic-Associated FSGS Enrolled in the DUPLEX Trial
Clinical Journal of the American Society of Nephrology – 2025
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Publications
Results55
Lived Experiences of Patients and Care Providers in Focal Segmental Glomerular Sclerosis and IgA Nephropathy
Glomerular Diseases – 2025
Targeting Endothelin and Angiotensin Pathways for Kidney Function Preservation in Glomerular Disease
European Medical Journal – 2026
Association Between Complete Proteinuria Remission and Kidney Function in Phase 3 PROTECT Trial of Sparsentan in IgA Nephropathy
Clinical Journal of the American Society of Nephrology – 2025
KDIGO 2025 Clinical Practice Guideline for the Management of Immunoglobulin A Nephropathy (IgAN) and Immunoglobulin A Vasculitis (IgAV)
Kidney International – 2025
Not funded by Travere
Efficacy and Safety of ACE Inhibitor and Angiotensin Receptor Blocker Therapies in Primary Focal Segmental Glomerulosclerosis Treatment: A Systematic Review and Meta-Analysis
Kidney Medicine – 2022
Congress materials
Results130
Patients With Focal Segmental Glomerulosclerosis Achieved Low Proteinuria Targets Earlier and More Often With Sparsentan vs Irbesartan in DUPLEX
World Congress of Nephrology (WCN) – 2026
PROTECT Post Hoc Analysis: Efficacy of Sparsentan (SPAR) vs. Irbesartan (IRB) in Patients (Pts) with IgAN ≤12 mo vs. >12 mo from Kidney Biopsy
World Congress of Nephrology (WCN) – 2026
Outcomes of renal transplantation in FSGS and IgA Nephropathy in the UK RaDaR registry mapped to post-transplant proteinuria control
World Congress of Nephrology (WCN) – 2026
Impact of histology on efficacy of sparsentan therapy in IgA nephropathy: central biopsy review of patients in the PROTECT trial
World Congress of Nephrology (WCN) – 2026
PROTECT Post Hoc Analysis: Efficacy of Sparsentan (SPAR) vs. Irbesartan (IRB) in Patients (Pts) with IgAN ≤12 mo vs. >12 mo from Kidney Biopsy
World Congress of Nephrology (WCN) – 2026
Sparsentan reversibly decreases mesangial IgA deposition in gddY mice; a possible role for mesangial cell surface autoantigen expression
World Congress of Nephrology (WCN) – 2026
Events
Results19
Past
March 28–31, 2026 – Yokohama, Japan
World Congress of Nephrology (WCN) 2026
Upcoming
October 21–25, 2026 – Denver, CO
American Society of Nephrology (ASN) Kidney Week 2026
Coming soon
Upcoming
August 3–7, 2026 – Maui, HI
GlomCon Hawaii 2026
Upcoming
November 12–16, 2026 – Galveston, TX
International Society of Glomerular Disease (ISGD) Clinical Trials Summit 2026
Upcoming
June 20–24, 2026 – Boston, MA
American Transplant Congress (ATC) 2026
Upcoming
June 3–6, 2026 – Glasgow, Scotland
63rd European Renal Association (ERA) Congress 2026
Downloadable resources
Results7
KDIGO 2025 Infographic
FILSPARI US PI
FSGS Mechanism of Action
Travere Infographic-Overview of data on concomitant use of sparsentan and SGLT2i in IgA nephropathy
Travere Therapeutics – PROTECT 2-year findings Infographic Dec 2024
Kohan Infographic
Abstracts
Results48
Pivotal Results of the Phase 3 PROTECT Trial of Sparsentan (SPAR) vs Irbesartan (IRB) in Patients (Pts) With Immunoglobulin A Nephropathy (IgAN)
Concomitant Sparsentan and Sodium-Glucose Cotransporter-2 Inhibitors (SGLT2is) in Patients With IgA Nephropathy (IgAN) in the PROTECT Open-Label Extension (OLE)
Sparsentan as First-Line Treatment of Incident Patients With IgA Nephropathy: Preliminary Findings From the SPARTAN Trial
Sparsentan Receptor Occupancy Modeling, Clinical Actions, and Safety Visual Abstract
Pivotal Results of the Phase 3 PROTECT Trial of Sparsentan (SPAR) vs Irbesartan (IRB) in Patients (Pts) With Immunoglobulin A Nephropathy (IgAN)
Sparsentan (SPAR) vs Irbesartan (IRB) in Patients With Focal Segmental Glomerulosclerosis (FSGS): Results From the Phase 3 DUPLEX Trial